Functionalization of extracellular matrix (ECM) on multichannel biphasic calcium phosphate (BCP) granules for improved bone regeneration
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چکیده
منابع مشابه
Bone regeneration in critical-sized bone defect enhanced by introducing osteoinductivity to biphasic calcium phosphate granules.
OBJECTIVES Biphasic calcium phosphate (BCP) is frequently used as bone substitute and often needs to be combined with autologous bone to gain an osteoinductive property for guided bone regeneration in implant dentistry. Given the limitations of using autologous bone, bone morphogenetic protein-2 (BMP2)-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particles (BMP2-cop.Bio...
متن کاملAlendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation
Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes. However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation. To enhance osteogenic differentiation, we prepared alendronate- (ALN-) eluting BCP scaffolds. The coating of ALN on BCP scaffolds was confirmed by scanni...
متن کاملBone Regeneration of Decellularized In-Vivo Deposited Extracellular Matrix (ECM) on Hydroxyapatite Sponge Scaffold
Submit Manuscript | http://medcraveonline.com of polysaccharides and proteins, such as collagens, proteoglycans and glycoproteins that are essential in tissue engineering [3]. Cellular interactions with the ECM are known to play a critical role in providing structural support to cells, directing cell function, and regulating development, homeostasis, and repair of a variety of tissues [4-8]. EC...
متن کاملInfluence of strontium on the synthesis and surface properties of biphasic calcium phosphate (BCP) bioceramics.
PURPOSE Biphasic calcium phosphate (BCP) ceramics are suitable for synthetic bone applications. The strontium substituted calcium phosphate ceramics have potential for use in orthopedic surgeries. Aim of the present work is to introduce strontium into BCP (composed of hydroxyapatite and tricalcium phosphate) ceramics and to study their bioactivity and mechanical properties. METHODS BCP cerami...
متن کاملBiphasic calcium phosphate ceramics in small bone defects: potential influence of carrier substances and bone marrow on bone regeneration.
OBJECTIVES Synthetic calcium phosphate bone substitutes such as hydroxyapatite (HA), beta-tricalcium phosphate (beta-TCP) or mixtures are alternatives to autogenous bone grafts. TricOs T((R)) and Collagraft((R)) are resorbable bone substitutes consisting of biphasic calcium phosphate and a bioactive matrix. Both products have a similar HA to beta-TCP ratio, but differ by their matrix. It was th...
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ژورنال
عنوان ژورنال: Materials & Design
سال: 2020
ISSN: 0264-1275
DOI: 10.1016/j.matdes.2020.108653